Biocatalytic Synthesis of Chiral Pharmaceutical Intermediates

Ramesh N. Patel

Process R & D, Bristol-Myers Squibb, New Brunswick, NJ 08903, USA

Article history:

Received July 29, 2004
Accepted November 22, 2004

Key words:

biocatalysis, chiral intermediates, antiviral, anticancer, antihypertensive, anti-infective, receptor agonists/antagonists, enantioselective enzymatic de-protection


The production of single enantiomers of drug intermediates has become increasingly important in the pharmaceutical industry. Chiral intermediates and fine chemicals are in high demand from both the pharmaceutical and agrochemical industries for the preparation of bulk drug substances and agricultural products. The enormous potential of microorganisms and enzymes for the transformation of synthetic chemicals with high chemo-, regio- and enantioselectivities has been demonstrated. In this article, biocatalytic processes are described for the synthesis of chiral pharmaceutical intermediates.

*Corresponding author:

Search FTB

Follow us

 facebook 1 twitter bird_icon LI In Bug


Environmental Policy

sdg publishers compact 4 300x300

QR Code


We use cookies to improve our website and your experience when using it. Cookies used for the essential operation of the site have already been set. To find out more about the cookies we use and how to delete them, see our privacy policy.

I accept cookies from this site.

EU Cookie Directive Module Information