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Silica-Lipid Hybrid Microparticles as Efficient Vehicles for Enhanced Stability and Bioaccessibility of Curcumin

Yudi Ma1,2,3orcid tiny, Qiang Wang1,2,3orcid tiny, Dantong Wang1,2,3orcid tiny, Juan Huang1,2,3orcid tiny, Rui Sun1,2orcid tiny, Xinyu Mao1,2orcid tiny Yuan Tian1,2orcid tiny and

Qiang Xia1,2,3*orcid tiny


1School of Biological Science and Medical Engineering, State Key Laboratory of Bioelectronics, Southeast University, No.2, Sipailou Street, 210096
 Nanjing, PR China
2National Demonstration Center for Experimental Biomedical Engineering Education, Southeast University, No. 2, Sipailou Street, 210096 Nanjing, PR China
3Collaborative Innovation Center of Suzhou Nano Science and Technology, No. 150 Renai Road 215123 Suzhou, PR China

Article history:
Received: 10 September 2018
Accepted: 6 August 2019

Key words:
curcumin, silica-lipid hybrid microparticles, antioxidant activity, bioaccessibility, storage stability

Curcumin is an active ingredient with multiple functions, but its application is often restricted due to its poor water solubility, weak stability, and consequently low bioaccessibility. Based on this, the aim of this work is to develop a new vehicle to overcome these restrictions. Here we developed a curcumin-loaded nanoemulsion and then curcumin-loaded silica-lipid hybrid microparticles through emulsification and vacuum drying, respectively. The loading of curcumin in the nanoemulsion and microparticles was (0.30±0.02) and (0.67±0.02) %, respectively. FTIR and XRD analyses of microparticles revealed that curcumin was encapsulated in porous, amorphous silica. In vitro antioxidant activities showed that the encapsulation would not affect the antioxidant activity of curcumin. In vitro simulated digestion indicated that nanoemulsion and microparticles had higher curcumin bioaccessibility than the control group. The storage stability of microparticles remained the same during 6 weeks in the dark at 4, 25 and 40 °C. Moreover, the microparticles had a better chemical stability than nanoemulsion under the light. The cell viability was over 80 % when the concentration of nanocarriers was less than 45 μg/mL. Hence, the microparticles could be a promising means to load curcumin and improve its solubility, light stability and bioaccessibility.



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