Novel Biocatalytic Methodology: Low Temperature Enhanced Enantioselectivity of Enzyme Catalyzed Reactions in Organic Solvents

Edina Ljubović, Maja Majerić-Elenkov, Amir Avdagić and Vitomir Šunjić*

»Ruđer Bošković« Institute, Bijenička c. 54, P. O. B. 1016, HR-10000 Zagreb, Croatia

Article history:

Received April 14, 1999
Accepted June 14, 1999

Key words:

kinetic resolution, desymmetrization, free-energy of activation


After recent reports in 1997/98, the low-temperature enhancement of enantioselectivity of the lipase-catalyzed acylations in organic solvents, emerges as a new lab-scale methodology in biocatalysis. The examples of effective production of enantiomerically pure compounds (EPC) at low temperatures, either by kinetic resolution of racemates or by desymmetrization of prochiral substrates, are reviewed. 

*Corresponding author:

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